9/18/2023 0 Comments Dmf vs dma polarity![]() Also it would be nice to not hand a process to a manufacturing chemist full of shitty solvents to work with. Reasons for looking for alternatives are for continuity of supply, i.e if I build a process around a solvent that is later restricted and then we cannot manufacture. Cost isnt that much of an issue due to the relatively low volumes used. Im not too fussed about solvent recovery, even scaled up the process will use relatively little solvent (~10-20L). All the excess solvent is removed from the product so no concerns here about labelling etc. ![]() ![]() I am doing a further reaction on the polymer in solution at 60C so rules out THF for use here. Chlorinated solvents wont be acceptable either due to hazards/waste. In this way, the preferred physicochemical space for SPPS could be identified and ultimately two binary mixtures, DMSO/DOL (3 : 7) and DMSO/2-Me-THF (3 : 7) generally. I have ruled out DMSO and dioxane due to insolubility. The viscosity and polarity of DMF and a wide range of green binary solvent mixtures were used to guide the synthesis of the short model peptides Ac-LVAYAG-NH 2 and Aib-enkephalin. Looking for alternatives for the usual dipolar aprotic solvents for solubilising polymers that arent so nasty/on the REACH watch list.Ĭant give too much away about what I'm doing, but its a linear polymer that I have found is only soluble in DMAc, NMP, THF, DMF, some chlorinated solvents also.
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